Publications:

 

2020

 

  • HEGER, Vladimír - BENEŠOVÁ, Barbora - VISKUPIČOVÁ, Jana - MÁJEKOVÁ, Magdaléna - ZOOFISHAN, Zoofishan - HUNYADI, Attila - HORÁKOVÁ, Ľubica**. Phenolic Compounds from Morus nigra Regulate Viability and Apoptosis of Pancreatic β-Cells Possibly via SERCA Activity. In ACS Medicinal Chemistry Letters, 2020, vol. 11, no. 5, p. 1006-1013.

 

  • HLAVÁČ, Matúš - KOVÁČIKOVÁ, Lucia - ŠOLTÉSOVÁ PRNOVÁ, Marta - ŠRAMEL, Peter - ADDOVÁ, Gabriela - MÁJEKOVÁ, Magdaléna - HANQUET, Gilles - BOHÁČ, A. - ŠTEFEK, Milan**. Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. In Journal of Medicinal Chemistry, 2020, vol. 63, no. 1, p. 369-381.

 

  • RODRÍGUEZ, Yoel - MÁJEKOVÁ, Magdaléna**. Structural Changes of Sarco/Endoplasmic Reticulum Ca2+-ATPase Induced by Rutin Arachidonate: A Molecular Dynamics Study. In Biomolecules : Open Access Journal, 2020, vol. 10, no. 2, art. no. 214. ISSN 2218-273X. available at <https://www.mdpi.com/2218-273X/10/2/214>

 

  • SILVA, Daniel Botelho - MENDES, Eduarda - SUMMERS, Eleanor J - NECA, Ana - JACINTO, Ana C. - REIS, Telma - AGOSTINHO, Paula - BOLEA, Irene - JIMENO, Luisa M. - MATEUS, Luisa M. - OLIVEIRA-CAMPOS, Ana M.F. - UNZETA, Mercedes - MARCO-CONTELLES, José - MÁJEKOVÁ, Magdaléna - RAMSAY, Rona R.** - CARREIRAS, Carmo M.**. Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents. In Drug Development Research, 2020, vol. 81, no. 2, p. 215-231.

 

  • CAPCAROVÁ, Marcela** - KALAFOVÁ, Anna - SCHWARZOVÁ, Marianna - SCHNEIDGENOVÁ, Monika - ŠOLTÉSOVÁ PRNOVÁ, Marta - ŠVÍK, Karol - SLOVÁK, Lukáš - KISSKA, Peter - KOVÁČIK, Anton - BRINDZA, Ján. Consumption of bee bread influences glycaemia and development of diabetes in obese spontaneous diabetic rats. In Biologia, 2020, vol. 75, no. 5, p. 705-711.

 

  • ŠOLTÉSOVÁ PRNOVÁ, Marta - KOVÁČIKOVÁ, Lucia - ŠVÍK, Karol - BEZEK, Štefan - ELMAZOGLU, Zübeyir - KARASU, Çimen - ŠTEFEK, Milan**. Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat - another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats. In Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, vol. 393, no. 4, p. 651-661.
  • ŠOLTÉSOVÁ PRNOVÁ, Marta** - RAČKOVÁ, Lucia - KOVÁČIKOVÁ, Lucia - BALLEKOVÁ, Jana - VISKUPIČOVÁ, Jana - MICHÁLIKOVÁ, Silvia - TASKOPARAN, Betul - ELMAZOGLU, Zübeyir - LANIŠNIK RIŽNER, Tea - KARASU, Çimen - BANERJEE, Sreeparna - ŠTEFEK, Milan. General toxicity assessment of the novel aldose reductase inhibitor cemtirestat. In Interdisciplinary toxicology, 2019, vol. 12, no. 3, p. 120-128. 

 

  • KOUTSOPOULOS, Konstantinos - LAVRENTAKI, Vasiliki - ANTONIOU, Ioakeim - KOUSAXIDIS, Antonios - LEFKOPOULOU, Matina - TSANTILI-KAKOULIDOU, Anna - KOVÁČIKOVÁ, Lucia - ŠTEFEK, Milan - NICOLAOU, Ioannis**. Design synthesis and evaluation of novel aldose reductase inhibitors: The case of indolyl–sulfonyl–phenols. In Bioorganic & Medicinal Chemistry, 2020, vol. 28, no. 15, art. no. 115575.

 

2019

 

 

  • ŠOLTÉSOVÁ PRNOVÁ, Marta - ŠVÍK, Karol - BEZEK, Štefan - KOVÁČIKOVÁ, Lucia - KARASU, Çimen - ŠTEFEK, Milan**. 3-Mercapto-5H-1,2,4-Triazino[5,6-b] Indole-5-Acetic Acid (Cemtirestat) Alleviates Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats: A Role of Aldose Reductase. In Neurochemical Research, 2019, vol. 44, no. 5, p. 1056-1064.

 

  • HLAVÁČ, Matúš - KOVÁČIKOVÁ, Lucia - ŠOLTÉSOVÁ PRNOVÁ, Marta - ŠRAMEL, HEGER, Vladimír* - TYNI, Jonna* - HUNYADI, Attila - HORÁKOVÁ, Ľubica - KAKKONEN-LAHTELA, Maija - RILLA-RAHNASTO, Minna**. Quercetin based derivatives as sirtuin inhibitors. In Biomedicine & Pharmacotherapy, 2019, vol. 111, p. 1326-1333.

 

  • KOPRDOVÁ, Romana - CSATLÓSOVÁ, Kristína - ĎURIŠOVÁ, Barbora - BÖGI, Eszter - MÁJEKOVÁ, Magdaléna - DREMENCOV, Eliyahu - MACH, Mojmír**. Electrophysiology and Behavioral Assessment of the New Molecule SMe1EC2M3 as a Representative of the Future Class of Triple Reuptake Inhibitors. In Molecules, 2019, vol. 24, no. 23, art. no. 4218.

 

Patent:

 

·          ŠTEFEK, Milan - BALLEKOVÁ, Jana - ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna. Použitie 5-karboxymetyl-1,2,3,4-tetrahydro-1H-pyrido[4,3-b]indolov a farmaceutický prostriedok s ich obsahom : udelenie patentu č. 288725 (09.12.2019), patentová prihláška značky spisu PP 50049-2016, (02.08.2016). Druh dokumentu: B6. M P T: A61K 31/00, A61P 9/00, A61P 13/00, A61P 15/00, A61P 19/00, A61P 25/00, A61P 27/00, A61P 35/00. Majiteľ patentu: Ústav experimentálnej farmakológie a toxikológie SAV, Dúbravská cesta 9, 841 04 Bratislava, SK. Banská Bystrica : Úrad priemyselného vlastníctva Slovenskej republiky, 2019. 14 s.

 

 

2018

 

  • KUČEROVÁ-CHLUPÁČOVÁ, Marta - DOSEDĚL, Martin - KUNEŠ, Jiří - ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna - ŠTEFEK, Milan. Chalcones and their pyrazine analogs: synthesis, inhibition of aldose reductase, antioxidant activity, and molecular docking study. In Monatshefte für Chemie - Chemical Monthly, 2018, vol. 149, no. 5, p. 921-929.

     

  • NOVÁK, David - VISKUPIČOVÁ, Jana - ZATLOUKALOVÁ, Martina - HEGER, Vladimír - MICHÁLIKOVÁ, Silvia - MÁJEKOVÁ, Magdaléna - VACEK, Jan. Electrochemical behavior of sarco/endoplasmic reticulum Ca-ATPase in response to carbonylation processes. In Journal of Electroanalytical Chemistry, 2018, vol. 812, p. 258-264.

     

  • VORČÁKOVÁ, Katarína - MÁJEKOVÁ, Magdaléna - HORÁKOVÁ, Eva - DRABINA, Pavel - SEDLÁK, Miloš - ŠTĚPÁNKOVÁ, Šárka. Synthesis and characterization of new inhibitors of cholinesterases based on N-phenylcarbamates: In vitro study of inhibitory effect, type of inhibition, lipophilicity and molecular docking. In Bioorganic Chemistry, 2018, vol. 78, p. 280-289.

  • ŽIŽKOVÁ, Petronela - VISKUPIČOVÁ, Jana - HEGER, Vladimír - RAČKOVÁ, Lucia - MÁJEKOVÁ, Magdaléna - HORÁKOVÁ, Ľubica. Dysfunction of SERCA pumps as novel mechanism of methylglyoxal cytotoxicity. In Cell Calcium, 2018, vol. 74, p. 112-122.

     

  • ULUSU, Nuray Nuriye - GÖK, Müslüm - SAKUL, Arzu Ayse Sayin - ARI, Nuray - ŠTEFEK, Milan - KARASU, Çimen. Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats. In Interdisciplinary toxicology, 2017, vol. 10, no. 4, p. 148-154.

 

2017

 

  • BALLEKOVÁ, Jana - ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna - ŠTEFEK, Milan. Does inhibition of aldose reductase contribute to the anti-inflammatory action of setipiprant? In Physiological Research, 2017, vol. 66, no. 4, p. 687-693.

  • MÁJEKOVÁ, Magdaléna - BALLEKOVÁ, Jana - PRNOVÁ, Marta - ŠTEFEK, Milan. Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity. In Bioorganic & Medicinal Chemistry, 2017, vol. 25, no. 24, p. 6353-6360.

  • PAPASTAVROU, Nikolaos - CHATZOPOULOU, Maria - BALLEKOVÁ, Jana - CAPPIELLO, Mario - MOSCHINI, Roberta - BALESTRI, Francesco - PATSILINAKOS, Alexandros - RAGNO, Rino - ŠTEFEK, Milan - NICOLAOU, Ioannis. Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation. In European Journal of Medicinal Chemistry, 2017, vol. 130, p. 328-335.

  • ŽIŽKOVÁ, Petronela - ŠTEFEK, Milan - RAČKOVÁ, Lucia - ŠOLTÉSOVÁ PRNOVÁ, Marta - HORÁKOVÁ, Ľubica. Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases. In Chemico-biological interactions, 2017, vol. 265, p. 36-46.

  • TASKOPARAN, Betul - SEZA, Esin Gulce - DEMIRKOL, Secil - TUNCER, Sinem - ŠTEFEK, Milan - GURE, Ali Osmay - BANERJEE, Sreeparna. Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer. In Cellular Oncology (Dordrecht), 2017, vol. 40, no. 6, p. 563-578.

  • KROŠLÁK, Erik - MALIAR, T. - NEMEČEK, Peter - VISKUPIČOVÁ, Jana - MALIAROVÁ, Mária - HAVRLENTOVÁ, Michaela - KRAIC, Ján. Antioxidant and proteinase inhibitory activities of selected poppy (Papaver somniferum L.) genotypes. In Chemistry and Biodiversity, 2017, vol. 14, no. 9, article number e1700176.

  • VISKUPIČOVÁ, Jana - ŽIŽKOVÁ, Petronela - RAČKOVÁ, Lucia - HORÁKOVÁ, Ľubica. Pycnogenol cytotoxicity in pancreatic INS-1E β cells induced by calcium dysregulation. In Phytotherapy Research, 2017, vol. 31, no. 11, p. 1702-1707.

  •  

    ULUSU, Nuray Nuriye - GÖK, Müslüm - SAKUL, Arzu Ayse Sayin - ARI, Nuray - ŠTEFEK, Milan - KARASU, Çimen. Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats. In Interdisciplinary toxicology, 2017, vol. 10, no. 4, p. 148-154.

     

  • VISKUPIČOVÁ, Jana - MALIAR, T. Rutin fatty acid esters: from synthesis to biological health effects and application. In Journal of Food and Nutrition Research, 2017, vol. 56, no. 3, p. 232-243.

  • HORÁKOVÁ, Ľubica. New strategies focused on endoplasmic reticulum for treatment of human diseases. In Medical Research and Innovations : open access, 2017, vol. 1, no. 3, p. 1. ISSN 2514-3700.
  • KOPRDOVÁ, Romana - OKULIAROVÁ, Monika - UJHÁZY, Eduard - MÁJEKOVÁ, Magdaléna - MACH, Mojmír. Behavioural analysis of new pyridoindole derivatives after chronic mild stress. In Toxicology Lettersr, 2017, vol. 280, suppl. 1, p. S226-S227.
  • RAMSAY, Rona R. - MÁJEKOVÁ, Magdaléna - MEDINA, Milagros - VALOTI, Massimo. Key targets for multi-target ligands designed to combat neurodegeneration. In Structure-based drug design for diagnosis and treatment of neurological diseases - Frontiers Media, 2017, p. 127-150.

 

 

2016

 

  • DIEZ-DACAL, Beatriz - SÁNCHEZ-GÓMEZ, Francisco J. - SÁNCHEZ-MURCIA, Pedro A. - MILÁČKOVÁ, Ivana - ZIMMERMAN, Tahl - BALLEKOVÁ, Jana - GARCÍA-MARTÍN, Elena - AGÚNDEZ, José A.G. - GHARBI, Severine - GAGO, Federico - ŠTEFEK, Milan - PÉREZ-SALA, Dolores. Molecular interactions and implications of aldose reductase inhibition by PGA1 and clinically used prostaglandins. In Molecular Pharmacology, 2016, vol. 89, n. 1, p. 42-52.
  • ENAYAT, Shabnam - CEYHAN, Seyma Muserref - TASKOPARAN, Betul - ŠTEFEK, Milan - BANERJEE, Sreeparna. CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo. In Archives of Biochemistry and Biophysics, 2016, vol. 596, p. 84-98.
  • ŠOLTÉSOVÁ PRNOVÁ, Marta - MILÁČKOVÁ, Ivana - ŠTEFEK, Milan. 3´-O-(3-Chloropivaloyl)quercetin, an α-glucosidase inhibitor with multitarget therapeutic potential in relation to diabetic complications. In Chemical Papers, 2016, vol. 70, no. 11, p. 1439-1444.
  • ŠTEFEK, Milan - ŠOLTÉSOVÁ PRNOVÁ, Marta - BALLEKOVÁ, Jana - MÁJEKOVÁ, Magdaléna. Cemtirestat, a novel aldose reductase inhibitor and antioxidant, in multitarget pharmacology of diabetic complications. In International Journal of Advances in Science, Engineering and Technology. - IRAJ, 2016, vol. 4, no. 3, p. 41-44. ISSN 2321-9009. Proceedings of research world international conference. - Muscat, Oman : IRAJ, 2016, p. 1-4. ISBN 978-93-86083-34-0.
  • RAMSAY, Rona R. - MÁJEKOVÁ, Magdaléna - MEDINA, Milagros - VALOTI, Massimo. Key targets for multi-target ligands designed to combat neurodegeneration. In Frontiers in Neuroscience, 2016, vol. 10, article number 375.

 

Patent Application:

 

ŠTEFEK, Milan - BALLEKOVÁ, Jana - ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna. Použitie 5-karboxymetyl-1,2,3,4-tetrahydro-1H-pyrido[4,3-b]indolov a farmaceutický prostriedok s ich obsahom : patentová prihláška PP 50049-2016, dátum podania prihlášky: 02.08.2016, medzinárodné patentové triedenie: A61K31/00 verzia MPT: 16, Prihlasovateľ: Ústav experimentálnej farmakológie a toxikológie SAV, Dúbravská cesta 9, 841 04 Bratislava, SK. Banská Bystrica : Úrad priemyselného vlastníctva Slovenskej republiky, 2016.

 

 

 

2015

 

  • HOUÉE-LÉVIN, Chantal - BOBROWSKI, K. - HORÁKOVÁ, Ľubica - KARADEMIR, B. - SCHÖNEICH, C. - DAVIES, M. J. - SPICKETT, Corinne M. Exploring oxidative modifications of tyrosine: An update on mechanisms of formation, advances in analysis and biological consequences. In Free Radical Research : official journal of the Society for Free Radical Research -European Region, 2015, vol. 49, no. 4, p. 347-373.
  • LINTNEROVÁ, Lucia - KOVÁČIKOVÁ, Lucia - HANQUET, Gilles - BOHÁČ, A. Selected methodologies convenient for the synthesis of N,5-diaryloxazole-2-amine pharmacophore. In Journal of Heterocyclic Chemistry, 2015, vol. 52, no. 2, p. 425-439.
  • MILÁČKOVÁ, Ivana - ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna - SOTNÍKOVÁ, Ružena - STAŠKO, Michal - KOVÁČIKOVÁ, Lucia - BANERJEE, Sreepama - VEVERKA, Miroslav - ŠTEFEK, Milan. 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent. In Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, vol. 30, no. 1, p.107-113.
  • ŠOLTÉSOVÁ PRNOVÁ, Marta - BALLEKOVÁ, Jana - GAJDOŠÍKOVÁ, Alena - GAJDOŠÍK, Andrej - ŠTEFEK, Milan. A novel carboxymethylated mercaptotriazinoindole inhibitor of aldose reductase interferens with the polyol pathway in streptozotocin-induced diabetic rats. In Physiological Research, 2015, vol. 64, no. 4, p. 587-591.
  • ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna - MILÁČKOVÁ, Ivana - DIEZ-DACAL, Beatriz - PÉREZ-SALA, Dolores - CEYHAN, Seyma Muserref - BANERJEE, Sreepama - ŠTEFEK, Milan. [5-(Benzyloxy)-1H-indol-1-yl]acetic acid, an aldose reductase inhibitor and PPARγ ligand. In Acta Biochimica Polonica, 2015, vol. 62, no. 3, p. 523-528.
  • ŠTEFEK, Milan - ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna - RECHLIN, Chris - HEINE, Andreas - KLEBE, Gerhard. Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold. In Journal of medicinal chemistry, 2015, vol. 58, no. 6, p. 2649-2657.
  • VISKUPIČOVÁ, Jana - ŠTROSOVÁ, Miriam - ŽIŽKOVÁ, Petronela - MÁJEKOVÁ, Magdaléna - HORÁKOVÁ, Ľubica. Rutin stimulates sarcoplasmic reticulum Ca2+-ATPase activity (SERCA1) and protects SERCA1 from peroxynitrite mediated injury. In Molecular and Cellular Biochemistry : an international journal for chemical biology in health and disease, 2015, vol. 402, iss. 1-2, p. 51-62.
  • VISKUPIČOVÁ, Jana - MÁJEKOVÁ, Magdaléna - HORÁKOVÁ, Ľubica. Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives. In Journal of Muscle Research and Cell Motility, 2015, vol. 36, p. 183-194.
  • MILÁČKOVÁ, Ivana - RAČKOVÁ, Lucia - MÁJEKOVÁ, Magdaléna - MRVOVÁ, Nataša - ŠTEFEK, Milan. Protection or cytotoxicity mediated by a novel quinonoid-polyphenol compound? In General Physiology and Biophysics, 2015, vol. 34, p. 51-64.
  • VISKUPIČOVÁ, Jana - BLAŠKOVIČ, Dušan - GALINIAK, Sabina - SOSZYNSKI, Miroslav - BARTOSZ, Gregorz - HORÁKOVÁ, Ľubica - SADOWSKA-BARTOSZ, Izabela. Effect of high glucose concentrations on human erythrocytes in vitro. In Redox Biology, 2015, vol. 5, p. 381-387.
  • KOVÁČIKOVÁ, Lucia - MÁJEKOVÁ, Magdaléna - ŠTEFEK, Milan. Substituted pyridoindoles as biological antioxidants: drug design, chemical synthesis, and biological activity. In Advanced protocols in oxidative stress III. - New York : Springer, 2015, p. 313-327. ISBN 978-1-4939-1440-1. ISSN 1064-3745.

 

 

 

Patent:

 

ŠTEFEK, Milan - MILÁČKOVÁ, Ivana - DIEZ-DACAL, Beatriz - PÉREZ-SALA, Dolores - ŠOLTÉSOVÁ PRNOVÁ, Marta. Use of 5-carboxymethyl-3-mercapto-1,2,4-triazino-[5,6-B]indoles and their pharmaceutical composition : international publication number WO 2015/057175 A1. International publication date: 23 april 2015 (23.04.2015). Applicant: Ústav experimentálnej farmakológie a toxikológie SAV, Dúbravská cesta 9, 841 04 Bratislava (SK). International patent classification: A61K 31/53 (2006.01). World Intellectual Property Organization, 2015.